Last edited by Mazujind
Tuesday, May 5, 2020 | History

4 edition of Tamoxifen and Beyond (Milestones in Drug Therapy) found in the catalog.

Tamoxifen and Beyond (Milestones in Drug Therapy)

Virgil C. Jordan

Tamoxifen and Beyond (Milestones in Drug Therapy)

by Virgil C. Jordan

  • 33 Want to read
  • 7 Currently reading

Published by Birkhauser .
Written in English

    Subjects:
  • Endocrinology & Metabolism,
  • Oncology,
  • Pharmacology,
  • Antiestrogenic treatment,
  • Aromatase inhibitors,
  • Breast cancer,
  • Chemoprevention,
  • Drug resistance,
  • Medical / Pharmacology,
  • Selective estrogen receptor modulation (SERM),
  • Medical,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    ID Numbers
    Open LibraryOL12866958M
    ISBN 103764370459
    ISBN 109783764370459

      Tamoxifen became the most investigated anticancer agent over the 40 years of its development. The success of the drug as an adjuvant therapy has been quantified: women with breast cancer are alive because of long-term tamoxifen treatment. Most importantly, the development of tamoxifen demonstrated that there was an advantage for patients by targeting the estrogen receptor . Notably, over 50% of recurrences and deaths occurred after 5 years of adjuvant therapy,3, 4 demonstrating the need for an effective therapy beyond the initial 5 years of adjuvant treatment.3, 4 Although the results from a number of extended tamoxifen trials are awaited, the results of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B trial, evaluating the efficacy of Cited by: 9.

    Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the FDA to treat people diagnosed with both early-stage and advanced-stage hormone-receptor-positive breast cancer. Learn more about tamoxifen in pill form. to benefit the most from tamoxifen therapy to extend the duration beyond 5 years." This author does note that specific trials, such as the Adjuvant Tamoxifen-Longer Against Shorter (ATLAS) and the Adjuvant Tamoxifen Treatment Offer More? (ATTOM), are underway to determine the Author: Keith E. Friend.

      The breast cancer drug Tamoxifen might well be marketed with the slogan, “If it doesn’t kill you, it will cure you”– except that would be an overstatement. The truth is that it probably won’t cure you of anything, but may very well kill you, as yet one more study makes clear. According to that study, just published in Cancer Research no less, long-term use of tamoxifen ups the risk. Tamoxifen. Tamoxifen is a hormone therapy for breast cancer in both women and men. It lowers the risk of early breast cancer coming back (recurring) after surgery or developing in the other breast. It can also control advanced breast cancer for some time.


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Tamoxifen and Beyond (Milestones in Drug Therapy) by Virgil C. Jordan Download PDF EPUB FB2

Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance.

This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research Format: Paperback. Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years.

Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen.

It is regrettably true that overviews, even when up to date after exhaustive research Manufacturer: Birkhäuser. Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance.

This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews. The covalent binding of Tamoxifen to proteins and DNA.- Tamoxifen metabolism and receptor function - implications for mechanisms of resistance in breast cancer.- Tamoxifen and E-cadherin/catenin complex.- Regulation of growth factor gene expression by Tamoxifen.- Tamoxifen and drug-metabolising enzymes.- For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial.

The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published.

Get this from a library. Tamoxifen: Beyond the Antiestrogen. [John A Kellen] -- Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years.

Following the many scientific papers and books on the subject, it has remained a very intriguing substance. Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years.

Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. Tamoxifen blocks the actions of estrogen, a female hormone.

Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer)/ Beyond The Shock is a collaborative breast cancer guide created by the National Breast Cancer Foundation, Inc.

(NBCF) with the support of the finest medical experts, doctors, and researchers in the world. NBCF utilized ground-breaking technology and the resources of the global medical community to create an accessible platform for understanding.

Summary. In a large randomized clinical trial, women with early-stage breast cancer who received 5 years of adjuvant treatment with tamoxifen had better outcomes up to 15 years after the start of treatment than those who received 2 years of tamoxifen therapy.

Risks of cancer recurrence, of cancer in the other breast, and of death from breast cancer were all lower in women who took tamoxifen. Tamoxifen citrate has a pKa' ofthe equilibrium solubility in water at 37°C is mg/mL and in N HCl at 37°C, it is mg/mL.

Tamoxifen - Clinical Pharmacology. Tamoxifen citrate is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems/ While most women take tamoxifen for 5 or 10 years, it hasn’t been clear if taking tamoxifen for fewer than 5 years offered benefits.

A Swedish study suggests that taking tamoxifen for 2 years offers long-term survival benefits for premenopausal women diagnosed with early-stage, estrogen-receptor-positive disease compared to no treatment after.

Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA.

The result is a reduction in DNA synthesis and cellular response to estrogen. Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men.

Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Patients on the tamoxifen arm of B and disease-free at 5 years were reassigned to an additional 5 years of tamoxifen therapy vs.

placebo. For patients on the placebo arm as compared with the tamoxifen arm, ongoing follow-up revealed an advantage beyond 5 years in terms of DFS, 92% vs.

86% (p); distant DFS, 96% vs. 90% (p); and. Tamoxifen's labeling notes that the drug should not be used with others that prolong the QT interval. This (the amount of time between two of the waves seen on an electrocardiogram), if significant, is said to raise the risk of an abnormal heart rhythm and, possibly, sudden death.

Before Using. Drug information provided by: IBM Micromedex. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

For this medicine, the following should be considered. Description and Brand Names. Drug information provided by: IBM Micromedex US Brand Name. Nolvadex; Soltamox; Descriptions. Tamoxifen is used to treat certain types of breast cancer (eg, estrogen receptor-positive breast cancer that has spread to other parts of the body [metastatic], early stage estrogen receptor-positive breast cancer after surgery and radiation treatment).

Tamoxifen may also cause irregular periods and sexual problems. When a woman takes tamoxifen to treat breast cancer, most doctors agree that the benefits of the drug are much greater than the Author: Debra Fulghum Bruce, Phd. New research shows that a lower dose of the hormone therapy Tamoxifen is as effective as the higher dose treatment in helping to prevent breast cancer from returning and.

Buy Tamoxifen: Beyond the Antiestrogen by Kellen, John A. (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible : John A. Kellen.Tamoxifen is a prescription drug.

It comes as an oral tablet and an oral solution. Tamoxifen oral tablet is only available as a generic drug. Generic drugs usually cost less than a brand-name drug.Tamoxifen is the generic form of the brand-name drug Soltamox, which is used to treat some types of breast cancer in men and women.

Tamoxifen is prescribed to treat metastatic breast cancer, or 3/5.